Is Schizophrenia a Syndrome of Accelerated Aging?
نویسندگان
چکیده
منابع مشابه
Is schizophrenia a syndrome of accelerated aging?
Schizophrenia is associated with a number of anatomical and physiological abnormalities outside of the brain, as well as with a decrease in average life span estimated at 20% in the United States. Some studies suggest that this increased mortality is not entirely due to associated causes such as suicide and the use of psychotropic medications. In this article, in order to focus greater attentio...
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Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated aging. While the underlying constitutional mutation leads to accelerated rates of DNA damage, it is not yet known whether WS is also associated with an increased epigenetic age according to a DNA methylation based biomarker of aging (the "Epigenetic Clock"). Using whole blood methylation data from 18 WS c...
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Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate th...
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متن کاملAging in Orthodox Seeds is a Problem
Seed deterioration is loss of seed quality, viability and vigor due to effect of adverse environmental factors. Many of our crops are reproduced through seeds, and throughout the world large quantities are produced, stored and transported. Seed ageing during storage may cause retardation of field establishment, and may eventually result in seedling abnormalities or even failure of emergence. Du...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2008
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbm140